Ilepatril (AVE7688) | Vasopeptidase inhibitor | Probechem Biochemicals

Chemical Structure : Ilepatril

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Ilepatril (AVE 7688, AVE7688)

货号: PC-60709Not For Human Use, Lab Use Only.

Ilepatril (AVE7688) is a potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively.

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生物&药学活性

Ilepatril (AVE7688) is a potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively.
Ilepatril (AVE7688) displays good in vitro selectivity over a large variety of targets.
Ilepatril (AVE7688) restores endothelial function by increasing the ratio of NO to O2- concentration and bioavailability of NO, prevents albuminuria and reduces the incidence and severity of glomerulosclerosis and tubulointerstitial damage in vivo.

物理化学性质&存储条件

分子量	418.508
分子式	C21H26N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-[[(2S)-2-(acetylthio)-1-oxo-3-methylpropyl]amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo-(4S,7S,12bR)-pyrido[2,1-a][2]benzazepine-4-carboxic acid

参考文献

1. Weckler N, et al. J Renin Angiotensin Aldosterone Syst. 2003 Sep;4(3):191-6.

2. Schäfer S, et al. Cardiovasc Res. 2003 Nov 1;60(2):447-54.

3. Schäfer S, et al. Diabetologia. 2004 Jan;47(1):98-103.

4. Schäfer S, et al. Eur J Pharmacol. 2004 Jan 26;484(2-3):361-2.

Ilepatril (AVE 7688, AVE7688)

生物&药学活性

物理化学性质&存储条件

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Ilepatril (AVE 7688, AVE7688)

生物&药学活性

物理化学性质&存储条件

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