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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-Iguratimod
Iguratimod

Chemical Structure : Iguratimod

CAS No.: 123663-49-0

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Iguratimod (TT-614, TT614)

货号: PC-45134Not For Human Use, Lab Use Only.

Iguratimod (TT-614) is an antirheumatic agent that acts as an inhibitor of COX-2 with IC50 of 20 μM, does not inhibit COX-1, also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 6.81 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Iguratimod (TT-614) is  an antirheumatic agent that acts as an inhibitor of COX-2 with IC50 of 20 μM, does not inhibit COX-1, also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 6.81 uM.
Iguratimod (TT-614) is a disease-modifying antirheumatic drug that inhibits NF-kappaB (NF-κB) p65 subunit (RelA) phosphorylation and nuclear translocation without affecting IKBα degradation.
Iguratimod (TT-614) inhibits LPS-stimulated production of TNF-α, IL-6, and IL-8 with decreasing mRNA levels (IL-6 and IL-8).
Iguratimod (TT-614) mainly targets Act1 to disrupt the interaction between Act1 and TRAF5 and IKKi in the IL-17 pathway of synoviocytes.
Iguratimod (TT-614) also exhibts selective MIF inhibition in vitro and in vivo.

物理化学性质&存储条件

分子量 374.3679
分子式 C17H14N2O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Methanesulfonamide, N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]-

参考文献

1. Luo Q, et al. J Immunol. 2013 Nov 15;191(10):4969-78.

2. Bloom J, et al. J Biol Chem. 2016 Dec 16;291(51):26502-26514.

3. Aikawa Y, et al. Inflamm Res. 2002 Apr;51(4):188-94.

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