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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-Ifidancitinib
Ifidancitinib

Chemical Structure : Ifidancitinib

CAS No.: 1236667-40-5

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Ifidancitinib (ATI-502, ATI-50002, R507)

货号: PC-49397Not For Human Use, Lab Use Only.

Ifidancitinib (ATI-502, ATI-50002, R507) is a potent and selective next-generation JAK1/3 inhibitor, potently inhibits γc cytokine signaling.

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5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ifidancitinib (ATI-502, ATI-50002, R507) is a potent and selective next-generation JAK1/3 inhibitor, potently inhibits γc cytokine signaling.
Ifidancitinib strongly inhibited IL-2-stimulated STAT5 phosphorylation in mouse T cells.
Ifidancitinib also exhibited potent inhibitory effects on JAK1/2-mediated IFN-γ signaling.
Ifidancitinib treatment significantly reduced the population of NKG2D+CD8+ T cells in a dose-dependent manner.
Ifidancitinib impaired murine T cell proliferation and human T cell function in vitro and in vivo.
Ifidancitinib prevented the onset of alopecia in alopecia areata (AA) skin grafted C3H/HeJ mice.
Ifidancitinib induced multiple co-inhibitory receptors in CD44+CD62L- CD8+ T cells.
Ifidancitinib exhibited potent anti-inflammatory effects both in vitro and in C3H/HeJ mice in vivo, suppressed IFN-γ signaling with the reduced expression of IFN-γ-dependent genes such as MHC class I, CXCL10, and CXCL11.

物理化学性质&存储条件

分子量 395.394
分子式 C20H18FN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-[[2-(4-fluoro-3-methoxy-5-methylanilino)-5-methylpyrimidin-4-yl]amino]-3H-1,3-benzoxazol-2-one

参考文献

1. Zhenpeng Dai, et al. Front Immunol. 2022 Sep 20;13:955038.

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