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首页-小分子抑制剂&激动剂-GPCR-Free Fatty Acid Receptor (FFAR)-Icosabutate
Icosabutate

Chemical Structure : Icosabutate

CAS No.: 1253909-57-7

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Icosabutate

货号: PC-27329Not For Human Use, Lab Use Only.

Icosabutate is a dual FFAR1/FFAR4 (GPR40/GPR120) agonist with EC50 of 10 μM and 15.5 μM, respectively, also is a partial agonist of PPARα with EC50 of 208 nM, inhibits the arachidonic acid cascade and exhibits antioxidant and anti-apoptotic activities.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Icosabutate is a dual FFAR1/FFAR4 (GPR40/GPR120) agonist with EC50 of 10 μM and 15.5 μM, respectively, also is a partial agonist of PPARα with EC50 of 208 nM, inhibits the arachidonic acid cascade and exhibits antioxidant and anti-apoptotic activities.

物理化学性质&存储条件

分子量 374.57
分子式 C24H38O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((5Z,8Z,11Z,14Z,17Z)-Icosa-5,8,11,14,17-pentaen-1-yl)oxy)butanoic acid

参考文献

1. Harrison SA, et al. J Hepatol. 2025 Aug;83(2):293-303.

2. Stokman G, et al. Liver Int. 2020 Nov;40(11):2860-2876.

3. van den Hoek AM, et al. Hepatol Commun. 2019 Dec 24;4(2):193-207.

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