Icalcaprant | KOR antagonist | Probechem Biochemicals

Chemical Structure : Icalcaprant

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Icalcaprant (CVL-354, CVL354)

货号: PC-23099Not For Human Use, Lab Use Only.

Icalcaprant (CVL-354) is a potent, selective kappa opioid receptor (KOR) antagonist with Ki of 1.47 nM and IC50 of 0.042 nM, 31-fold binding affinity selectivity over MOR.

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生物&药学活性

Icalcaprant (CVL-354) is a potent, selective kappa opioid receptor (KOR) antagonist with Ki of 1.47 nM and IC50 of 0.042 nM, 31-fold binding affinity selectivity over MOR.
Icalcaprant (CVL-354) blocks KOR-mediated motivational deficits in mice, dose-dependently reverses the suppression of progressive ratio responding induced by spiradoline.
CVL-354 dose-dependently reverses KOR and MOR-induced thermal analgesia.

物理化学性质&存储条件

分子量	406.49
分子式	C23H26N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-[[(2S)-2-(3-Methoxy-1-methyl-1H-pyrazol-4-yl)-1-pyrrolidinyl]methyl]phenoxy]benzamide

参考文献

1. Patent WO2018096510 A1 2018-05-31.

Icalcaprant (CVL-354, CVL354)

生物&药学活性

物理化学性质&存储条件

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Icalcaprant (CVL-354, CVL354)

生物&药学活性

物理化学性质&存储条件

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