Ibulocydine |CAS:1314096-68-8 Probechem Biochemicals

Chemical Structure : Ibulocydine

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Ibulocydine

货号: PC-62682Not For Human Use, Lab Use Only.

Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.

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生物&药学活性

Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.
Ibulocydine reduces the phosphorylation of RNA polymerase II at Ser-5 and Ser-2, down-regulates Mcl-1, survivin, and XIAP and induces apoptosis.
Ibulocydine shows effectivity in HCC xenografts with no toxic side effects.

物理化学性质&存储条件

分子量	458.269
分子式	C16H20BrN5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2S,3S,4S,5S)-5-(4-amino-6-bromo-5-carbamoyl-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate

参考文献

1. Cho SJ, et al. J Biol Chem. 2011 Jun 3;286(22):19662-71.

2. Park SS, et al. Radiother Oncol. 2014 Aug;112(2):295-301.

3. Park SS,, et al. Int J Biochem Cell Biol. 2017 Feb;83:47-55.

Ibulocydine

生物&药学活性

物理化学性质&存储条件

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Ibulocydine

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