Iboxamycin | Antibiotic | Probechem Biochemicals

Chemical Structure : Iboxamycin

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Iboxamycin (IBX)

货号: PC-21856Not For Human Use, Lab Use Only.

Iboxamycin (IBX) is a broad-spectrum ribosome-binding antibiotic with potent activity against Gram-positive and Gram-negative bacteria overcomes bacterial multidrug resistance.

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生物&药学活性

Iboxamycin (IBX) is a broad-spectrum ribosome-binding antibiotic with potent activity against Gram-positive and Gram-negative bacteria overcomes bacterial multidrug resistance.
Iboxamycin (IBX) displays activity against a strain of E. coli resistant to cephalosporin, fluoroquinolone, tetracycline and aminoglycoside antibiotics (MIC = 8 μg ml−1) Clinical strains of Neisseria gonorrhoeae isalso highly susceptible (MIC = 0.125 μg ml−1) to Iboxamycin (IBX).
Iboxamycin (IBX) is non-haemolytic and non-toxic towards mammalian cells.
Iboxamycin (IBX) is orally bioavailable, safe and effective in treating both Gram-positive and Gram-negative bacterial infections in mice.

物理化学性质&存储条件

分子量	495.07
分子式	C22H39ClN2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 7-chloro-6,7,8-trideoxy-6-[[[(4S,5aS,8S,8aR)-octahydro-4-(2-methylpropyl)-2H-oxepino[2,3-c]pyrrol-8-yl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside

参考文献

1. Aleksandrova EV, et al. Nat Chem Biol. 2024 Jan 18. doi: 10.1038/s41589-023-01525-w.

2. Mitcheltree MJ, et al. Nature. 2021 Nov;599(7885):507-512.

Iboxamycin (IBX)

生物&药学活性

物理化学性质&存储条件

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Iboxamycin (IBX)

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物理化学性质&存储条件

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