Ibodutant | NK2 receptor antagonist| ProbeChem Biochemicals

Chemical Structure : Ibodutant

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Ibodutant (MEN-15596, MEN15596)

货号: PC-70191Not For Human Use, Lab Use Only.

Ibodutant (MEN-15596) is a potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3.

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生物&药学活性

Ibodutant (MEN-15596) is a potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3.
Ibodutant (MEN-15596) displays >1,000-fold selectivity over NK1 and NK3 (pKb<6).
Ibodutant (MEN-15596) induces a concentration-dependent rightward shift of the [βAla(8)]NKA(4-10) concentration-response curves without depressing the maximal contractile effect (3-100 nM).
Ibodutant (MEN-15596) shows good in vivo activity after intravenous, intraduodenal, and oral administration in guinea pigs.

物理化学性质&存储条件

分子量	644.866
分子式	C37H48N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-N-(1-(((R)-1-oxo-3-phenyl-1-(((1-((tetrahydro-2H-pyran-4-yl)methyl)piperidin-4-yl)methyl)amino)propan-2-yl)carbamoyl)cyclopentyl)-2,3-dihydrobenzo[b]thiophene-2-carboxamide

参考文献

1. Meini S, et al. J Pharmacol Exp Ther. 2009 May;329(2):486-95.

2. Fedi V, et al. J Med Chem. 2007 Oct 4;50(20):4793-807.

3. Santicioli P, et al. Eur J Pharmacol. 2013 Feb 28;702(1-3):32-7.

Ibodutant (MEN-15596, MEN15596)

生物&药学活性

物理化学性质&存储条件

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Ibodutant (MEN-15596, MEN15596)

生物&药学活性

物理化学性质&存储条件

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