Ibetazol | Importin β inhibitor | Probechem Biochemicals

Chemical Structure : Ibetazol

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Ibetazol (CDD-03, Inhibitor of importin beta)

货号: PC-23494Not For Human Use, Lab Use Only.

Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1.

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生物&药学活性

Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1.
Ibetazol interacts with cysteine 585 in importin β1, and thereby effectively prohibits both direct and adaptor (importin α) protein-dependent importin β1-mediated nuclear import.
Ibetazol has EC50 of 6.3 uM in phenotypic importin α1 translocation assays, with no cytotoxicity in HEK293T cells.
Ibetazol specifically inhibit importin β1-dependent import (the direct importin β1 dependent cargo SREBP1, importin α1, and importin β1-importin α cargos).

物理化学性质&存储条件

分子量	300.30
分子式	C13H11F3N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(ethylsulfinyl)-4-phenyl-6-(trifluoromethyl)pyrimidine

参考文献

1. Vercruysse T, et al. Commun Biol. 2024 Nov 23;7(1):1560.

Ibetazol (CDD-03, Inhibitor of importin beta)

生物&药学活性

物理化学性质&存储条件

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Ibetazol (CDD-03, Inhibitor of importin beta)

生物&药学活性

物理化学性质&存储条件

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