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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-Iberiotoxin
Iberiotoxin

Chemical Structure : Iberiotoxin

CAS No.: 129203-60-7

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Iberiotoxin (IbTX)

货号: PC-60654Not For Human Use, Lab Use Only.

Iberiotoxin (IbTX) is a selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM.

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100 ug ￥3280 In stock
500 ug ￥5480 In stock
1 mg ￥8580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Iberiotoxin (IbTX) is a selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM.
Iberiotoxin reversibly blocks PK,Ca in excised membrane patches from bovine aortic smooth muscle.

物理化学性质&存储条件

分子量 4230
分子式 C179H274N50O55S7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: 0.70 mg/ml
Chemical Name/SMILES

XFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ (Modifications: X-1 = pGlu, Disulfide bridge between 7 - 28,13 - 33,17 - 35)

参考文献

1. Nausch B, et al. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.

2. Suarez-Kurtz G, et al. J Pharmacol Exp Ther. 1991 Oct;259(1):439-43.

3. Galvez A, et al. J Biol Chem. 1990 Jul 5;265(19):11083-90.

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