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首页-小分子抑制剂&激动剂-Apoptosis-Apoptosis Inducer-Iberin
Iberin

Chemical Structure : Iberin

CAS No.: 505-44-2

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Iberin

货号: PC-42374Not For Human Use, Lab Use Only.

Iberin is an isothiocyanate compound from horseradish that exhibits anticancer activity, a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa, and significantly induces Nrf2 nuclear translocation in NIH3T3 fibroblasts.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Iberin is an isothiocyanate compound from horseradish that exhibits anticancer activity, a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa, and significantly induces Nrf2 nuclear translocation in NIH3T3 fibroblasts; induces cell cycle arrest and apoptosis in human neuroblastoma cells associated with inhibition of expression of Cdk2, Cdk4, and Cdk6 proteins.

物理化学性质&存储条件

分子量 163.26106
分子式 C5H9NOS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

Ethanol: 10 mg/mL
Chemical Name/SMILES

Propane, 1-isothiocyanato-3-(methylsulfinyl)-

参考文献

1. Jadhav U, et al. Int J Mol Med. 2007 Mar;19(3):353-61.

2. Jadhav U, et al. J Pharmacol Sci. 2007 Feb;103(2):247-51.

3. Jakobsen TH, et al. Appl Environ Microbiol. 2012 Apr;78(7):2410-21.

4. Tan SY, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6648-59.

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