IY7640 | Influenza HA inhibitor | Probechem Biochemicals

Chemical Structure : IY7640

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IY7640 (IY-7640)

货号: PC-72998Not For Human Use, Lab Use Only.

IY7640 (IY-7640) is a small molecule targeting the stalk region of the influenza HA protein, blocks HA-mediated membrane fusion of H1N1, H3N2, and influenza B viruses in cells.

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生物&药学活性

IY7640 (IY-7640) is a small molecule targeting the stalk region of the influenza HA protein, blocks HA-mediated membrane fusion of H1N1, H3N2, and influenza B viruses in cells.
IY7640 demonstrated potency against H1N1, H3N2, H5N1, H7N9, and H9N2 subtypes of IAV, including the 2009 pandemic H1N1 (pH1N1) virus (A/Korea/01/2009, rK09), with EC50 of 0.62-220 uM in plaque reduction assay in MDCK cells.
IY7640 successfully inhibited rK09 replication in cells at a level comparable to that of oseltamivir, K09 HA fusion was inhibited only by 1 uM IY7640.
The stalk region of the influenza HA protein is highly conserved across different (sub)types of influenza viruses.

物理化学性质&存储条件

分子量	445.442
分子式	C23H22F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(2-methoxyphenyl)piperazin-1-yl)(5-methyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)methanone

参考文献

1. Jin Il Kim, et al. J Virol. 2019 Aug 13;93(17):e00878-19.

IY7640 (IY-7640)

生物&药学活性

物理化学性质&存储条件

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IY7640 (IY-7640)

生物&药学活性

物理化学性质&存储条件

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