IXA4 | IRE1/XBP1s activator | Probechem Biochemicals

Chemical Structure : IXA4

CAS No.: 1185329-96-7

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IXA4 (IRE1 activator)

货号: PC-23415Not For Human Use, Lab Use Only.

IXA4 is a specific activator of IRE1/XBP1s signalling activator, promotes IRE1-dependent XBP1 splicing, selective activates the IRE1/XBP1s signaling.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

IXA4 is a specific activator of IRE1/XBP1s signalling activator, promotes IRE1-dependent XBP1 splicing, selective activates the IRE1/XBP1s signaling.
IXA4 does not affect the UPR or other stress-responsive signaling pathways.
IXA4 increases IRE1 RNase activity through a mechanism independent of binding the IRE1 nucleotide-binding pocket.
IXA4 is distinct from currently available IRE1 activators, which bind the kinase active site.
IXA4 improves ER proteostasis of AD-relevant APP mutants, reducing the secretion of Aβ through the increased targeting of APP to degradation.
IXA4 reduces mitochondrial dysfunction associated with mutant APP overexpression, likely reflecting the reduced intracellular APP afforded by compound treatment.

物理化学性质&存储条件

分子量	436.51
分子式	C24H28N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-1-acetamide, N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]-

参考文献

1. Grandjean JMD, et al. Nat Chem Biol. 2020 Oct;16(10):1052-1061.

IXA4 (IRE1 activator)

生物&药学活性

物理化学性质&存储条件

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IXA4 (IRE1 activator)

生物&药学活性

物理化学性质&存储条件

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