IWP-O1 |CAS:2074607-48-8 Probechem Biochemicals

Chemical Structure : IWP-O1

CAS No.: 2074607-48-8

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IWP-O1 (Porcupine inhibitor IWP-O1)

货号: PC-62803Not For Human Use, Lab Use Only.

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor with EC50 of 80 pM in L-Wnt-STF cells, effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.

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10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2780	In stock
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生物&药学活性

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor with EC50 of 80 pM in L-Wnt-STF cells, effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
IWP-O1 suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM, 2.5 times more active than LGK974.
IWP-O1 exhibits significantly improved metabolic stability, and suitable for model studies in mice.

物理化学性质&存储条件

分子量	432.487
分子式	C26H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-phenyl-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl)-N-(5-phenylpyridin-2-yl)acetamide

参考文献

1. You L, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.

IWP-O1 (Porcupine inhibitor IWP-O1)

生物&药学活性

物理化学性质&存储条件

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IWP-O1 (Porcupine inhibitor IWP-O1)

生物&药学活性

物理化学性质&存储条件

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