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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Porcupine-IWP-L6
IWP-L6

Chemical Structure : IWP-L6

CAS No.: 1427782-89-5

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IWP-L6 (IWP L6, Porcupine inhibitor)

货号: PC-49489Not For Human Use, Lab Use Only.

IWP-L6 is a potent, selective inhibitor of Porcupine with EC50 of 0.5 nM.

规格 价格 库存 数量
10 mg ￥680 In stock
25 mg ￥1180 In stock
50 mg ￥1980 In stock
100 mg ￥3480 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IWP-L6 is a potent, selective inhibitor of Porcupine with EC50 of 0.5 nM.
IWP-L6 effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses.
IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys.

物理化学性质&存储条件

分子量 472.58
分子式 C25H20N4O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide

参考文献

1. Wang, X., et al., et al. J Med Chem, 2013. 56(6): p. 2700-4.

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