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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PPAR-IVA-337
IVA-337

Chemical Structure : IVA-337

CAS No.: 927961-18-0

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IVA-337 (Lanifibranor, IVA337)

货号: PC-61592Not For Human Use, Lab Use Only.

IVA-337 (Lanifibranor, IVA337)) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively.

规格 价格 库存 数量
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg ￥5280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IVA-337 (Lanifibranor, IVA337) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively.
IVA-337 (Lanifibranor, IVA337) reduces skin fibrosis in the mouse, and suppresses inflammation in vivo.

物理化学性质&存储条件

分子量 434.909
分子式 C19H15ClN2O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(1-(1,3-Benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl)butanoic acid

参考文献

1. Ruzehaji N, et al. Ann Rheum Dis. 2016 Dec;75(12):2175-2183.

2. Avouac J, et al. Ann Rheum Dis. 2017 Aug 11. pii: annrheumdis-2016-210821.

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