IV-255 | BRG1 selective inhibitor | Probechem Biochemicals

Chemical Structure : IV-255

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IV-255 (IV 255)

货号: PC-21072Not For Human Use, Lab Use Only.

IV-255 is a next-generation selective inhibitor of BRG1 bromodomain, inhibits SWI/SNF complex and enhances DNA damage and cell death in glioblastoma.

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生物&药学活性

IV-255 is a next-generation selective inhibitor of BRG1 bromodomain, inhibits SWI/SNF complex and enhances DNA damage and cell death in glioblastoma.
IV-255 only enhances TMZ-induced death in GBM cells that express the BRG1 subunit, has no such effect in BRG1KO GBM cells.
IV-255 increases the amount of DNA-damage induced by TMZ and bleomycin.
IV-255 (20 uM, 24h) inhibits cell invasion and IFN-induced gene expression in MT330 and LN229 GBM cells.
IV-255 reduces the IFN-induced expression of CXCl11, increases IFN-induced expression of STAT1, IRF1 and IRF7 in GBM cell lines.

物理化学性质&存储条件

分子量	359.38
分子式	C19H19F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N1[C@@](C2)([H])CN(C3=CC=C(OC)C=C3)[C@@]2([H])C1)NC4=CC=C(F)C(F)=C4

参考文献

1. Chuanhe Yang, et al. J Cell Mol Med. 2023 Aug 18.

IV-255 (IV 255)

生物&药学活性

物理化学性质&存储条件

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IV-255 (IV 255)

生物&药学活性

物理化学性质&存储条件

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