IU-1 |CAS:314245-33-5 Probechem Biochemicals

Chemical Structure : IU-1

CAS No.: 314245-33-5

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IU-1 (USP14 inhibitor IU1)

货号: PC-61234Not For Human Use, Lab Use Only.

IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.

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25 mg	￥1680	In stock
100 mg	￥4580	In stock
250 mg	￥8680	In stock
1 g		Get quote

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生物&药学活性

IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.
IU-1 (USP14 inhibitor IU1) displays no activity against other human eight DUBs (Uch37, Uch-L1/L3, USP7, etc.).
IU-1 (USP14 inhibitor IU1) enhances proteasomal degradation in vivo, attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; also inhibits Dengue virus replication.

物理化学性质&存储条件

分子量	300.377
分子式	C18H21FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone

参考文献

1. Lee BH, et al. Nature. 2010 Sep 9;467(7312):179-84.

2. Nag DK, et al. Virus Res. 2012 Apr;165(1):103-6.

3. Lahaie N, et al. J Biol Chem. 2016 Mar 25;291(13):7156-70.

4. Min JW, et al. J Neurochem. 2017 Mar;140(5):826-833.

IU-1 (USP14 inhibitor IU1)

生物&药学活性

物理化学性质&存储条件

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IU-1 (USP14 inhibitor IU1)

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