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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-ITZ-1
ITZ-1

Chemical Structure : ITZ-1

CAS No.: 1180532-17-5

ITZ-1 (ITZ1)

货号: PC-63360Not For Human Use, Lab Use Only.

ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation.
    ITZ-1 causes mild Raf-1 degradation, but scarcely induces degradation of a broad range of Hsp90 client proteins by binding to the Hsp90 C terminus.
    ITZ-1 suppresses both IL-1β-induced proteoglycan and collagen release from bovine nasal cartilage in vitro and suppresses intra-articular infusion of IL-1β-induced cartilage proteoglycan degradation in rat knee joints.

    物理化学性质&存储条件

    分子量 541.57
    分子式 C20H20F5N3O3S3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-{(1Z)-5,6-Dimethyl3-oxo-8-[(4,4,5,5,5,-pentafluoropentyl)thio]-2,3-dihydro-1H-imidazo[5,1-c][1,4]thiazin-1-ylidene}-4methylbenzenesulfonamide

    参考文献

    1. Kimura H, et al. Chem Biol. 2010 Jan 29;17(1):18-27.

    2. Kimura H, et al. J Pharmacol Sci. 2009 Jun;110(2):201-11.

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