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ITYR-DBRMD

Chemical Structure : ITYR-DBRMD

CAS No.: 1809339-61-4

ITYR-DBRMD

货号: PC-38163Not For Human Use, Lab Use Only.

ITYR-DBRMD is a first-in-class inhibitor of enzyme iodothyronine deiodinase type 3 (DIO3) with antitumor effects both in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ITYR-DBRMD is a first-in-class inhibitor of enzyme iodothyronine deiodinase type 3 (DIO3) with antitumor effects both in vitro and in vivo.
    ITYR-DBRMD demonstrated attenuated cell counts, induction in apoptosis, and a reduction in cell proliferation in DIO3-positive HGSOC cells (OVCAR3 and KURAMOCHI), but not in DIO3-negative normal ovary cells (CHOK1) and OVCAR3 depleted for DIO3 or its substrate, T3.

    物理化学性质&存储条件

    分子量 670.818
    分子式 C13H7Br2I2NO5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid

    参考文献

    1. Dotan Moskovich, et al. Oncogene. 2021 Nov;40(44):6248-6257.

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