ITRI-E-(S)4046 | ROCK/MYLK4 inhibitor | Probechem Biochemicals

Chemical Structure : ITRI-E-(S)4046

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ITRI-E-(S)4046 (E(S)4046)

货号: PC-21300Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

ITRI-E-(S)4046 (E(S)4046) is a potent, highly specific, dual synergistic inhibitor of myosin light chain kinase 4 (MYLK4) and Rho-related protein kinase (ROCK) with IC50 of 3.2 nM and 25.6 nM for ROCK1 and MYLK4, respectively.
ITRI-E-(S)4046 potently inhibits myosin light chain (MLC) phosphorylation (pMLC) with IC50 of 50.4 nM in HTM cells.
ITRI-E-(S)4046 exhibits a selective kinase inhibition profile targeting on the AGC kinase subfamily, and MYLK4, shows high specificity against protein kinase A, G, and C families.
ITRI-E-(S)4046 can reduceintraocular pressure (IOP) in normotensive and hypertensive animal models.

物理化学性质&存储条件

分子量	306.37
分子式	C18H18N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-(1H-pyrazol-4-yl)phenyl)-3-amino-2-phenylpropanamide

参考文献

1. Yi-Hsun Chen, et al. Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):12.

ITRI-E-(S)4046 (E(S)4046)

生物&药学活性

物理化学性质&存储条件

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ITRI-E-(S)4046 (E(S)4046)

生物&药学活性

物理化学性质&存储条件

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