ITI-333 | 5-HT2A agonist | Probechem Biochemicals

Chemical Structure : ITI-333

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ITI-333 (ITI 333)

货号: PC-22332Not For Human Use, Lab Use Only.

ITI-333 is a potent, brain-penetrant, orally bioavailable 5-HT2A receptor antagonist (Ki =8 nM) and a biased, partial agonist at μ-opioid (MOP) receptors (Ki =11 nM, lacking β-arrestin agonism).

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生物&药学活性

ITI-333 is a potent, brain-penetrant, orally bioavailable 5-HT2A receptor antagonist (Ki =8 nM) and a biased, partial agonist at μ-opioid (MOP) receptors (Ki =11 nM, lacking β-arrestin agonism).
ITI-333 also displays antagonist activity at adrenergic α1A (Ki = 28 nM) and dopamine D1 (Ki=50 nM) receptors.
ITI-333 displays properties anticipated to aid in opioid withdrawal and prevent opioid relapse for sustainable long-term recovery.
ITI-333 has a low liability for abuse and safety issues in self-administration, physical tolerance/dependence, and gastrointestinal (GI) and pulmonary function assays.

物理化学性质&存储条件

分子量	381.45
分子式	C22H24FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6bR,10aS)-8-[3-(4-fluorophenoxy)propyl]-6b,7,8,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-2(3H)-one

参考文献

1. Gretchen L Snyder, et al. Psychopharmacology (Berl). 2024 May 6. doi: 10.1007/s00213-024-06578-w

ITI-333 (ITI 333)

生物&药学活性

物理化学性质&存储条件

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ITI-333 (ITI 333)

生物&药学活性

物理化学性质&存储条件

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