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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-ITF-6475
ITF-6475

Chemical Structure : ITF-6475

CAS No.: 2760854-72-4

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ITF-6475 (ITF6475)

货号: PC-25614Not For Human Use, Lab Use Only.

ITF-6475 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.7 nM (human full-length HDAC6), ITF-6475 is highly selective for the CD2 domain (zHDAC6-CD2), shows <10,000-fold selectivity for HDAC6 over all other HDAC subtypes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ITF-6475 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.7 nM (human full-length HDAC6), ITF-6475 is highly selective for the CD2 domain (zHDAC6-CD2), shows <10,000-fold selectivity for HDAC6 over all other HDAC subtypes.

物理化学性质&存储条件

分子量 436.43
分子式 C21H18F2N8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(1-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)benzyl)-1H-1,2,3-triazol-4-yl)phenyl)-4,5-dihydro-1H-imidazol-2-amine

参考文献

1. Edoardo Cellupica, et al. J Biol Chem. 2023 Jan;299(1):102800.

2. Guido Cavaletti, et al. Toxics. 2025 Sep 10;13(9):767.

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