ITD-1 | TGF-β inhibitor | Probechem Biochemicals

Chemical Structure : ITD-1

CAS No.: 1099644-42-4

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ITD-1 (ITD1)

货号: PC-43159Not For Human Use, Lab Use Only.

ITD-1 is a potent, selective TGF-β inhibitor that induces type II TGFβ receptor (TGFBR2) degradation with IC50 of 0.85 uM, enhances proteasomal degradation of TGFBR2.

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5 mg	￥680	In stock
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

ITD-1 is a potent, selective TGF-β inhibitor that induces type II TGFβ receptor (TGFBR2) degradation with IC50 of 0.85 uM, enhances proteasomal degradation of TGFBR2.
ITD-1 effectively clears the receptor from the cell surface and selectively inhibits intracellular signaling.
ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells.

物理化学性质&存储条件

分子量	415.524
分子式	C27H29NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: < 9 mg/mL
Chemical Name/SMILES	3-Quinolinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-, ethyl ester

参考文献

1. Willems E, et al. Cell Stem Cell. 2012 Aug 3;11(2):242-52.

2. Sun Z, et al. Dev Biol. 2017 Jan 15;421(2):149-160.

3. Mingyuan X, et al. Oncotarget. 2017 Dec 14;9(3):3188-3197.

ITD-1 (ITD1)

生物&药学活性

物理化学性质&存储条件

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ITD-1 (ITD1)

生物&药学活性

物理化学性质&存储条件

参考文献

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