IT1t dihydrochloride | CXCR4 inhibitor | Probechem Biochemicals

Chemical Structure : IT1t dihydrochloride

CAS No.: 1092776-63-0

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IT1t dihydrochloride (Isothiourea 1t dihydrochloride)

货号: PC-42391Not For Human Use, Lab Use Only.

IT1t (Isothiourea 1t) dihydrochloride is a highly potent, selective, orally bioavailable CXCR4 inhibitor with binding IC50 of 8 nM for hCXCR4, IC50 of 1.1 nM in Ca2+-mobilization assays.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

IT1t (Isothiourea 1t) dihydrochloride is a highly potent, selective, orally bioavailable CXCR4 inhibitor with binding IC50 of 8 nM for hCXCR4, IC50 of 1.1 nM in Ca2+-mobilization assays.
IT1t inhibits HIV-1IIIB attachment with IC50 of 7 nM, and IC90 of 100 nM.
IT1t also show promising anti-tumor effects, impairs the formation of TNBC early metastases in a zebrafish xenograft model.

物理化学性质&存储条件

分子量	479.57334
分子式	C21H36Cl2N4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Carbamimidothioic acid, N,N'-dicyclohexyl-, (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester, hydrochloride (1:2)

参考文献

1. Wu B, et al. Science. 2010 Nov 19;330(6007):1066-71.

2. Thoma G, et al. J Med Chem. 2008 Dec 25;51(24):7915-20.

3. Das D, et al. Antimicrob Agents Chemother. 2015 Apr;59(4):1895-904.

4. Tulotta C, et al. Dis Model Mech. 2016 Feb;9(2):141-53.

IT1t dihydrochloride (Isothiourea 1t dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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IT1t dihydrochloride (Isothiourea 1t dihydrochloride)

生物&药学活性

物理化学性质&存储条件

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