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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-IT-901
IT-901

Chemical Structure : IT-901

CAS No.: 1584121-99-2

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IT-901 (IT 901, IT901)

货号: PC-61961Not For Human Use, Lab Use Only.

IT-901 is a novel potent, small molecule inhibitor of NF-κB subunit c-Rel, inhibits DNA binding of c-Rel and NF-κB activity with IC50 of 3 uM.

规格 价格 库存 数量
5 mg ￥2880 In stock
10 mg ￥4580 In stock
25 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IT-901 is a novel potent, small molecule inhibitor of NF-κB subunit c-Rel, inhibits DNA binding of c-Rel and NF-κB activity with IC50 of 3 uM.
IT-901 reduces stimulation of the oxidative stress response gene heme oxygenase-1.
IT-901 inhibits c-Rel/NF-κB both in vitro and in vivo.

物理化学性质&存储条件

分子量 342.37
分子式 C17H14N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-[(2,4-dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

参考文献

1. Shono Y, et al. Cancer Res. 2016 Jan 15;76(2):377-89.

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