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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-IT-603
IT-603

Chemical Structure : IT-603

CAS No.: 292168-90-2

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IT-603 (IT 603, IT603)

货号: PC-70271Not For Human Use, Lab Use Only.

IT-603 is a small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥2980 In stock
50 mg ￥4580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IT-603 is a small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.
IT-603 inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM.
IT-603 binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity.

物理化学性质&存储条件

分子量 329.168
分子式 C11H9BrN2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one

参考文献

1. Shono Y, et al. Cancer Discov. 2014 May;4(5):578-91.

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