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首页-小分子抑制剂&激动剂-GPCR-Proton-sensing GPCRs-ISX-9
ISX-9

Chemical Structure : ISX-9

CAS No.: 832115-62-5

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ISX-9 (Isoxazole 9)

货号: PC-42974Not For Human Use, Lab Use Only.

ISX-9 (Isoxazole 9) is a isoxazole stem cell-modulator small molecule and GPR68 ligand through a chemical biology-target discovery strategy to GPR68, a proton (pH) sensing G protein-coupled receptor.

规格 价格 库存 数量
5 mg ￥680 In stock
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ISX-9 (Isoxazole 9) is a isoxazole stem cell-modulator small molecule and GPR68 ligand through a chemical biology-target discovery strategy to GPR68, a proton (pH) sensing G protein-coupled receptor.
ISX-9  induces neuronal differentiation of GPR68-expressing cells in hippocampus and primary cultures.
ISX-9 and GPR68 coregulates neuronal target genes such as Bex1 (brain-enriched X-linked protein-1) in hippocampal neural progenitors (HCN cells).
ISX-9  pharmacologically targets type 1 neural stem cells (NSCs), promoting neurogenesis in young mice, depleting the progenitor pool without adversely affecting hippocampal learning and memory function.

物理化学性质&存储条件

分子量 234.2743
分子式 C11H10N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 37 mg/mL
Chemical Name/SMILES

3-Isoxazolecarboxamide, N-cyclopropyl-5-(2-thienyl)-

参考文献

1. Schneider JW, et al. ACS Chem Neurosci. 2012 Jul 18;3(7):557-68.

2. Schneider JW, et al. Nat Chem Biol. 2008 Jul;4(7):408-10.

3. Bettio LE, et al. Neuroscience. 2016 Sep 22;332:212-22.

4. Bettio LEB, et al. Neurogenesis (Austin). 2017 Jun 1;4(1):e1317692.

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