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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-ISS610
ISS610

Chemical Structure : ISS610

CAS No.: 725233-55-6

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ISS610 (ISS-610)

货号: PC-26446Not For Human Use, Lab Use Only.

ISS610 (ISS-610) is a selective peptidomimetic inhibitor of STAT3 dimerization with IC50 of 42 uM for STAT-DNA binding disruption, interacts with SH2 domain of STAT3 and shows 7.4-fold selective over STAT1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ISS610 (ISS-610) is a selective peptidomimetic inhibitor of STAT3 dimerization with IC50 of 42 uM for STAT-DNA binding disruption, interacts with SH2 domain of STAT3 and shows 7.4-fold selective over STAT1.

    物理化学性质&存储条件

    分子量 503.45
    分子式 C23H26N3O8P
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-((S)-2-(4-Cyanobenzamido)-3-(4-(phosphonooxy)phenyl)propanamido)-4-methylpentanoic acid

    参考文献

    1. Shahani VM, et al. Bioorg Med Chem. 2011 Mar 1;19(5):1823-38.

    2. Gunning PT, et al. Bioorg. Med. Chem. Lett. 2007;17:1875.

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