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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PERK-ISRIB
ISRIB

Chemical Structure : ISRIB

CAS No.: 548470-11-7

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ISRIB (cis-ISRIB)

货号: PC-38450Not For Human Use, Lab Use Only.

cis-ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM.
ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, displays significant enhancement in spatial and fear-associated learning.
ISRIB is a potent inhibitor of the integrated stress response (ISR)integrated stress response (ISR).

物理化学性质&存储条件

分子量 451.34
分子式 C22H24Cl2N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N′-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]

参考文献

1. Sidrauski C, et al. Elife. 2015 Feb 26;4:e05033.

2. Sidrauski C, et al. Elife. 2013 May 28;2:e00498.

3. Halliday M, et al. Cell Death Dis. 2015 Mar 5;6:e1672.

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