ISQ-1

Chemical Structure : ISQ-1

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货号: PC-21892Not For Human Use, Lab Use Only.

ISQ-1 is a potent in vitro inhibitor of several cancer cell lines (LS174T cell proliferation, IC50=100 nM), inhibits Wnt signaling and also activates adenosine monophosphate kinase (AMPK).

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生物&药学活性

ISQ-1 is a potent in vitro inhibitor of several cancer cell lines (LS174T cell proliferation, IC50=100 nM), inhibits Wnt signaling and also activates adenosine monophosphate kinase (AMPK).
ISQ-1 inhibits in vitro cell growth of colon cancer LS174T, prostate cancer PC-3, sarcoma SK-LMS-1 and liver cancer HepG2 cell lines at nanomolar concentrations.
ISQ-1 also inhibits Wnt signaling target genes including c-Myc and axin2 and activates AMPK in a dose-dependent manner.
ISQ-1 inhibits mitochondrial ETC (electron transport chain) complex I in LS174T cells.
ISQ-1 synergizes with PLK inhibitor BI2536, inhibits the G2/M transition on cell cycle of LS174T colorectal cancer cells.
ISQ-1 (100 nM, 300 nM) inhibits mouse colon cancer organoids from Apcf/+/KrasLSL-G12D/Villin-Cre mouse model.
ISQ-1 (20 mg/kg/day) and the Plk1 inhibitor BI2536 (30 mg/kg twice a week) synergistically induced regression of LS174T colon cancer cell xenografts in nude mice.

物理化学性质&存储条件

分子量	316.41
分子式	C20H20N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N7,N7 -dimethyl-3-(1-methyl-1H-indol-3-yl)quinoline-2,7-diamine

参考文献

1. Xie Y, et al. Mol Cancer Ther. 2021 Oct;20(10):1893-1903.

ISQ-1

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ISQ-1

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