ISM042-2-048 | CDK20 inhibitor | Probechem Biochemicals

Chemical Structure : ISM042-2-048

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ISM042-2-048 (ISM 042-2-048)

货号: PC-49785Not For Human Use, Lab Use Only.

ISM042-2-048 is a potent, selective inhibitor of cyclin-dependent kinase 20 (CDK20, cell cycle-related kinase/CCRK) with IC50 of 33.4 nM (CDK20/CycT1), Kd value of 566 nM.

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生物&药学活性

ISM042-2-048 is a potent, selective inhibitor of cyclin-dependent kinase 20 (CDK20, cell cycle-related kinase/p42 CCRK) with IC50 of 33.4 nM (CDK20/CycT1), Kd value of 566 nM.
ISM042-2-048 demonstrated selective anti-proliferation activity in an HCC cell line with CDK20 overexpression, Huh7, with an IC50 of 208.7 ± 3.3 nM, compared to a counter screen cell line HEK293 (IC50 = 1706.7 ± 670.0 nM).
ISM042-2-048 is a tool molecule to evaluate biological functions for CDK20.
CDK20, also known as cell cycle-related kinase (CCRK), is overexpressed in many tumor cell lines including tumor samples from patients with different types of cancer, such as colorectal cancer, hepatocellular carcinoma (HCC), lung cancer, and ovarian carcinoma.

物理化学性质&存储条件

分子量	333.36
分子式	C17H15N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((7-(1H-pyrazol-4-yl)quinazolin-2-yl)amino)-N-methyl-1H-pyrrole-2-carboxamide

参考文献

1. Ren F, et al. Chem Sci. 2023 Jan 10;14(6):1443-1452.

ISM042-2-048 (ISM 042-2-048)

生物&药学活性

物理化学性质&存储条件

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ISM042-2-048 (ISM 042-2-048)

生物&药学活性

物理化学性质&存储条件

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