ISCK03 | c-Kit inhibitor | Probechem Biochemicals

Chemical Structure : ISCK03

CAS No.: 945526-43-2

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ISCK03 (ISCK 03, ISCK-03)

货号: PC-42389Not For Human Use, Lab Use Only.

ISCK03 is a specific c-Kit inhibitor that inhibits c-kit phosphorylation in vitro and SCF-induced c-kit phosphorylation in human melanoma cells.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
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生物&药学活性

ISCK03 is a specific c-Kit inhibitor that inhibits c-kit phosphorylation in vitro and SCF-induced c-kit phosphorylation in human melanoma cells.
ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, does not inhibit HGF-induced phosphorylation of p44/42 ERK proteins.
ISCK03 induces the dose-dependent depigmentation of newly regrown hair, promotes the depigmentation of UV-induced hyperpigmented spots in vivo; orally acitve.

物理化学性质&存储条件

分子量	355.45394
分子式	C19H21N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 38 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-

参考文献

1. Na YJ, et al. Biochem Pharmacol. 2007 Sep 1;74(5):780-6.

2. Kamlah F, et al. Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1541-9.

3. Hirano T, et al. Mol Cancer. 2015 Apr 19;14:90.

ISCK03 (ISCK 03, ISCK-03)

生物&药学活性

物理化学性质&存储条件

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ISCK03 (ISCK 03, ISCK-03)

生物&药学活性

物理化学性质&存储条件

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