ISCA2 inhibitor 25

Chemical Structure : ISCA2 inhibitor 25

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货号: PC-49374Not For Human Use, Lab Use Only.

ISCA2 inhibitor 25 is a selective, orally available small molecule inhibitor of HIF-2α with IC50 of 0.92 uM, decrease HIF-1/2α levels and induce ferroptosis by targeting Iron Sulfur Cluster Assembly 2 (ISCA2), a component of the late mitochondrial Iron Sulfur Cluster (L-ISC) assembly complex.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ISCA2 inhibitor 25 is a selective, orally available small molecule inhibitor of HIF-2α with IC50 of 0.92 uM, decrease HIF-1/2α levels and induce ferroptosis by targeting Iron Sulfur Cluster Assembly 2 (ISCA2), a component of the late mitochondrial Iron Sulfur Cluster (L-ISC) assembly complex.
ISCA2 inhibitor 25 decreases HIF-2α protein levels by blocking iron-responsive element (IRE)-dependent translation, and at higher concentrations, also decreases HIF-1α translation through unknown mechanisms.
ISCA2 inhibitor 25 triggers the iron starvation response, resulting in iron/metals overload and death via ferroptosis.
ISCA2 inhibitor 25 (60 mg/kg) significantly reduced ccRCC xenograft growth in vivo, decreased HIF-α levels and increased lipid peroxidation, suggesting increased ferroptosis in vivo.

物理化学性质&存储条件

分子量	368.353
分子式	C17H16N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3,4-dimethoxyphenyl)-N-(4-methoxy-1H-imidazo[4,5-c]pyridin-2-yl)-1,3,4-oxadiazol-2-amine

参考文献

1. Green YS, et al. Oncogene. 2022 Sep 12. doi: 10.1038/s41388-022-02460-1.