ISA-2011B |CAS:1395347-24-6 Probechem Biochemicals

Chemical Structure : ISA-2011B

CAS No.: 1395347-24-6

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ISA-2011B (ISA2011B, ISA 2011B)

货号: PC-45095Not For Human Use, Lab Use Only.

ISA-2011B (ISA2011B, ISA 2011B) is a poent, selective inhibitor of Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ISA-2011B (ISA2011B, ISA 2011B) is a poent, selective inhibitor of Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα).
ISA-2011B exhibits the highest binding affinity to PIP5K1α, and to MARK1 and MARK4 as well.
ISA-2011B targets PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways.
ISA-2011B significantly inhibits growth of tumor cells in xenograft mice.

物理化学性质&存储条件

分子量	423.849
分子式	C22H18ClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 57 mg/mL
Chemical Name/SMILES	5H-1,3-Dioxolo[4,5-g]pyrazino[1,2-b]isoquinoline-7,10-dione, 5-(5-chloro-1H-indol-3-yl)-8,9,10a,11-tetrahydro-9-methyl-, (5S,10aS)

参考文献

1. Semenas J, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3689-98.

2. Kunkl M, et al. Front Immunol. 2017 Apr 26;8:502.

ISA-2011B (ISA2011B, ISA 2011B)

生物&药学活性

物理化学性质&存储条件

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ISA-2011B (ISA2011B, ISA 2011B)

生物&药学活性

物理化学性质&存储条件

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