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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-IS811
IS811

Chemical Structure : IS811

CAS No.: 276698-73-8

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IS811 (IS 811, IS-811)

货号: PC-73259Not For Human Use, Lab Use Only.

IS811 is a potent, selective CCR3 antagonist with IC50 of 2.0 nM, potently inhibits chemotaxis with EC50 of 19 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    IS811 is a potent, selective CCR3 antagonist with IC50 of 2.0 nM, potently inhibits chemotaxis with EC50 of 19 nM.
    IS811 displays >100-fold selectivity over 5-HT2a, DAT and NET.
    IS811 (0-20 mg/kg) dose-dependently inhibited eotaxin-induced eosinophil influx to the lung in vivo.

    物理化学性质&存储条件

    分子量 453.602
    分子式 C27H36FN3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Urea, N-(3-acetylphenyl)-N'-[3-[(2S,4R)-4-[(4-fluorophenyl)methyl]-1-propyl-2-piperidinyl]propyl]-

    参考文献

    1. Paul S Watson, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5695-9.

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