IRE1α inhibitor 16 | IRE1α inhibitor | Probechem Biochemicals

Chemical Structure : IRE1α inhibitor 16

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IRE1α inhibitor 16 (Amgen IRE1α inhibitor 16)

货号: PC-22296Not For Human Use, Lab Use Only.

IRE1α inhibitor 18 is a potent, selective and allosteric inhibitor of IRE1α endonuclease activity with enzyme IC50 of 13 nM, cellular IRE1α IC50 of 99 nM in XBP1-Luc cellular assays.

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IRE1α inhibitor 18 is a potent, selective and allosteric inhibitor of IRE1α endonuclease activity with enzyme IC50 of 13 nM, cellular IRE1α IC50 of 99 nM in XBP1-Luc cellular assays.
IRE1α inhibitor 18 is selective in kinase screens.

物理化学性质&存储条件

分子量	615.15
分子式	C32H31ClN6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[[3-[2-[(trans-4-Aminocyclohexyl)amino]-4-pyrimidinyl]-2-pyridinyl]oxy]-3-methyl-1-naphthalenyl]-2-chlorobenzenesulfonamide

参考文献

1. Paul E Harrington, et al. ACS Med Chem Lett. 2014 Sep 24;6(1):68-72.

IRE1α inhibitor 16 (Amgen IRE1α inhibitor 16)

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IRE1α inhibitor 16 (Amgen IRE1α inhibitor 16)

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物理化学性质&存储条件

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