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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-IRE1-IRE1α-IN-3
IRE1α-IN-3

Chemical Structure : IRE1α-IN-3

CAS No.: 1414938-21-8

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IRE1α-IN-3

货号: PC-62196Not For Human Use, Lab Use Only.

IRE1α-IN-3 is a novel, potent IRE1α RNase inhibitor with EC50 of 0.82 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    IRE1α-IN-3 is a novel, potent IRE1α RNase inhibitor with EC50 of 0.82 uM.
    IRE1α-IN-3 demonstrates dose-dependent reduction of IRE1α kinase autophosphorylation amd inhibition of XBP1 RNA cleavage in the WT cell lines.

    物理化学性质&存储条件

    分子量 504.517
    分子式 C27H23F3N6O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-(8-amino-3-isopropylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea

    参考文献

    1. Wang L, et al. Nat Chem Biol. 2012 Dec;8(12):982-9.

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