IRBM6 | Class I HDAC inhibitor | Probechem Biochemicals

Chemical Structure : IRBM6

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IRBM6 (Class I HDAC-IN-6)

货号: PC-72886Not For Human Use, Lab Use Only.

IRBM6 (Class I HDAC-IN-6) is a potent, class I selective HDAC inhibitor with EC50 of 50 nM (HeLa cellular), HDAC1/2/3 IC50 of 1.7/2.8/1.1 nM.

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生物&药学活性

IRBM6 (Class I HDAC-IN-6) is a potent, class I selective HDAC inhibitor with EC50 of 50 nM (HeLa cellular), HDAC1/2/3 IC50 of 1.7/2.8/1.1 nM.
IRBM6 weakly inhibits HDAC6 (IC50=177 nM) and is inactive at 5 uM against HDACs 4-7.
IRBM6 showed a potent inhibitory effect on the growth TC-797s and two additional NUT carcinoma (NC) cell lines, PER-403, and 10-15.
IRBM6 induces a transcriptional program of differentiation in NC cells, demonstrated large-scale changes in gene expression that were significantly enriched with differentiation gene sets and depleted of pro-growth gene sets, including those of MYC and E2F targets.
IRBM6 repressed growth and induced differentiation of NUT carcinoma (NC) cells in proportion to inhibition of NUT transcriptional activity.

物理化学性质&存储条件

分子量	478.593
分子式	C27H34N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)-7-oxononyl)-1-methylazetidine-3-carboxamide

参考文献

1. Alberto Bresciani, et al. ACS Med Chem Lett. 2018 Nov 27;10(4):481-486.

2. Hitoshi Shiota, et al. Mol Cancer Res. 2021 Nov;19(11):1818-1830.

IRBM6 (Class I HDAC-IN-6)

生物&药学活性

物理化学性质&存储条件

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IRBM6 (Class I HDAC-IN-6)

生物&药学活性

物理化学性质&存储条件

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