IRAK4 inhibitor 23 | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : IRAK4 inhibitor 23

CAS No.: 1820787-94-7

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IRAK4 inhibitor 23 (IRAK4-IN-1)

货号: PC-61623Not For Human Use, Lab Use Only.

IRAK4 inhibitor 23 is a potent, selective, orally bioavailable IRAK4 inhibitor with IC50 of 7 nM.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

IRAK4 inhibitor 23 is a potent, selective, orally bioavailable IRAK4 inhibitor with IC50 of 7 nM.
IRAK4 inhibitor 23 inhibits R848 (TLR7 agonist) stimulated cytokine release in hPBMC with IC50 of 300 nM.
IRAK4 inhibitor 23 exhibits excellent pharmacokinetic profile and kinase selectivity (99%).
IRAK4 inhibitor 23 demonstrates activity in vivo via oral dosing in TLR7 driven model of inflammation.

物理化学性质&存储条件

分子量	337.427
分子式	C19H23N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((1r,4r)-4-morpholinocyclohexyl)amino)quinazoline-6-carbonitrile

参考文献

1. Smith GF, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.

IRAK4 inhibitor 23 (IRAK4-IN-1)

生物&药学活性

物理化学性质&存储条件

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IRAK4 inhibitor 23 (IRAK4-IN-1)

生物&药学活性

物理化学性质&存储条件

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