IRAK4-IN-16 | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : IRAK4-IN-16

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IRAK4-IN-16 (IRAK4 inhibitor 16)

货号: PC-60980Not For Human Use, Lab Use Only.

IRAK4-IN-16 is a potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

IRAK4-IN-16 is a potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively.
IRAK4-IN-16 inhibits IL-1 induced activation of NF-kB in primary human monocytes with IC50 of 0.3 uM.
IRAK4-IN-16 possesses excellent selectivity and pharmacokinetic properties.

物理化学性质&存储条件

分子量	478.519
分子式	C27H25F3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-phenyl-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

参考文献

1. Wang Z, et al. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5546-50.

IRAK4-IN-16 (IRAK4 inhibitor 16)

生物&药学活性

物理化学性质&存储条件

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IRAK4-IN-16 (IRAK4 inhibitor 16)

生物&药学活性

物理化学性质&存储条件

参考文献

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