IR-IGF-1R heterodimer modulator HI-2

Chemical Structure : IR-IGF-1R heterodimer modulator HI-2

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货号: PC-23218Not For Human Use, Lab Use Only.

HI-2 is a small molecule modulator of insulin receptor-insulin like growth factor-1 receptor heterodimers, inhibits insulin receptor/IGF-1 receptor hybrid formation, with no effects on IR or IGF-1R.

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250 mg		Get quote

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生物&药学活性

HI-2 is a small molecule modulator of insulin receptor-insulin like growth factor-1 receptor heterodimers, inhibits insulin receptor/IGF-1 receptor hybrid formation, with no effects on IR or IGF-1R.
HI-2 reduced expression of the negative regulatory p85α subunit of phosphatidylinositol 3-kinase, increased basal phosphorylation of the downstream target Akt and enhanced insulin/insulin-like growth factor-1 and shear stress-induced serine phosphorylation of Akt.
HI-2 significantly reduced hybrid expression in saphenous vein endothelial cells (SVEC) from patients with type 2 diabetes mellitus.

物理化学性质&存储条件

分子量	433.52
分子式	C27H23N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(3-methylbenzyl)-1H-1,2,4-triazol-3-yl)-2-(p-tolyl)quinoline-4-carboxamide

参考文献

1. Myers CG, et al. Mol Cell Endocrinol. 2024 Oct 15:112387.