IQS-019 mesylate | BCR signaling inhibitor | Probechem Biochemicals

Chemical Structure : IQS-019 mesylate

加入收藏

IQS-019 mesylate (IQS 019, IQS019)

货号: PC-60404Not For Human Use, Lab Use Only.

IQS-019 mesylate is a potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IQS-019 mesylate is a potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively.
IQS-019 mesylate inhibits at least 20% of the kinase activity at 0.1 uM) and an almost complete kinase inactivation at the 10 uM in a set of 17 TK/TKLs.
IQS-019 mesylate impaires cell proliferation, reduces CXCL12-dependent cell migration, and induces caspase-dependent apoptosis.
IQS-019 mesylate shows improved efficacy in vitro and in vivo compared to ibrutinib.

物理化学性质&存储条件

分子量	606.523
分子式	C26H29Cl2N7O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-6-(2,6-dichlorophenyl)-8-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one methanesulfonate

参考文献

1. Balsas P, et al. J Hematol Oncol. 2017 Mar 31;10(1):80.

2. Puig de la Bellacasa R, et al. Eur J Med Chem. 2014 Oct 30;86:664-75.

IQS-019 mesylate (IQS 019, IQS019)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

IQS-019 mesylate (IQS 019, IQS019)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.