IQS-019 | BCR signaling inhibitor |Probechem Biochemicals

Chemical Structure : IQS-019

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IQS-019 (IQS 019;IQS019)

货号: PC-60403Not For Human Use, Lab Use Only.

IQS-019 is a potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively.

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生物&药学活性

IQS-019 is a potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively.
IQS-019 inhibits at least 20% of the kinase activity at 0.1 uM) and an almost complete kinase inactivation at the 10 uM in a set of 17 TK/TKLs.
IQS-019 impaires cell proliferation, reduces CXCL12-dependent cell migration, and induces caspase-dependent apoptosis; shows improved efficacy in vitro and in vivo compared to ibrutinib.

物理化学性质&存储条件

分子量	510.423
分子式	C25H25Cl2N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-6-(2,6-dichlorophenyl)-8-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. Balsas P, et al. J Hematol Oncol. 2017 Mar 31;10(1):80.

2. Puig de la Bellacasa R, et al. Eur J Med Chem. 2014 Oct 30;86:664-75.

IQS-019 (IQS 019;IQS019)

生物&药学活性

物理化学性质&存储条件

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IQS-019 (IQS 019;IQS019)

生物&药学活性

物理化学性质&存储条件

参考文献

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