IQ-1 |CAS:331001-62-8 Probechem Biochemicals

Chemical Structure : IQ-1

CAS No.: 331001-62-8

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IQ-1 (p300/β-catenin inhibitor IQ1)

货号: PC-42676Not For Human Use, Lab Use Only.

A small molecule, specific inhibitor of p300/β-catenin interaction that binds to PR72/130 subunit of PP2A.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3780	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

IQ-1 is a small molecule, specific inhibitor of p300/β-catenin interaction that binds to PR72/130 subunit of PP2A.
IQ-1 decreases phosphorylation of p300 at Ser-89 and disrupts β-catenin/p300 interaction.
IQ-1 prevents β-catenin coactivator switching from CBP to p300, maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner.

物理化学性质&存储条件

分子量	362.42498
分子式	C21H22N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Acetamide, 2-[2-(4-acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)

参考文献

1. Miyabayashi T, et al. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668-73.

2. Rieger ME, et al. J Biol Chem. 2016 Mar 18;291(12):6569-82.

IQ-1 (p300/β-catenin inhibitor IQ1)

生物&药学活性

物理化学性质&存储条件

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IQ-1 (p300/β-catenin inhibitor IQ1)

生物&药学活性

物理化学性质&存储条件

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