IPR-179 | Gelatinase inhibitor | Probechem Biochemicals

Chemical Structure : IPR-179

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IPR-179 (ACT-03, IPR179)

货号: PC-72035Not For Human Use, Lab Use Only.

IPR-179 (ACT-03) is a potent, BBB-permeable, selective gelatinase (MMP2 and MMP9) inhibitor with IC50 of 656 nM and 310 nM, respectively.

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生物&药学活性

IPR-179 (ACT-03) is a potent, BBB-permeable, selective gelatinase (MMP2 and MMP9) inhibitor with IC50 of 656 nM and 310 nM, respectively.
IPR-179 dispalys high selectivity over MMP1/3/7/8, ADAM10/17, Prolyl oligopeptidase and DPP4 (IC50=3.3 uM->20 uM).
IPR-179 reduced seizure severity in the rapid-kindling rat model.
IPR-179 reduced the number of spontaneous seizures in the kainic acid model (during and up to 7 weeks after delivery) without side effects while improving cognitive behavior.
IPR-179 prevented an MMP2/9-dependent switch-off normally restraining network excitability during the activity period.

物理化学性质&存储条件

分子量	631.67
分子式	C29H41F4N5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((2S,3R)-1-(((S)-4-(3,5-difluorobenzamido)-1-(hydroxyamino)-1-oxobutan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-4,4-difluoro-1-hexanoyl-N-methylpyrrolidine-2-carboxamide

参考文献

1. Diede Wm Broekaart, et al. J Clin Invest. 2021 Jan 4;131(1):e138332.

2. Alexandra Bertran, et al. Bioorg Chem. 2020 Jan;94:103365.

IPR-179 (ACT-03, IPR179)

生物&药学活性

物理化学性质&存储条件

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IPR-179 (ACT-03, IPR179)

生物&药学活性

物理化学性质&存储条件

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