IPN60090 | GLS-1 inhibitor | Probechem Biochemicals

Chemical Structure : IPN60090

CAS No.: 1853164-83-6

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IPN60090 (IACS-6274, IACS6274, IPN 60090 )

货号: PC-21821Not For Human Use, Lab Use Only.

IPN60090 (IACS-6274) is a potent, selective glutaminase-1 (GLS-1) inhibitor with IC50 of 31 nM, inhibits proliferation of A549 cells with IC50 of 26 nM.

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5 mg	￥3480	In stock
10 mg	￥5480	In stock
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100 mg		Get quote

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生物&药学活性

IPN60090 (IACS-6274) is a potent, selective glutaminase-1 (GLS-1) inhibitor with IC50 of 31 nM, inhibits proliferation of A549 cells with IC50 of 26 nM.
IPN60090 (IACS-6274) displays no activity observed against GLS-2 (IIC50>50 uM), shows no significant inhibition of the hERG channel or common cytochrome P450 enzymes, as well as a 97-member Eurofins DiscoverX kinase panel.
IPN60090 (IACS-6274) demonstrates robust in vivo target engagement when orally dosed to this model at doses of 25-100 mg/kg twice daily, at both 4 days and 28 days, inhibits tumor growth in Ru337 PDX subcutaneous mouse tumor model.
IPN60090 can specifically bind to the ZSWIM4 protein, exerts a significant chemosensitizing effect in both EOC cells and PDO models.

物理化学性质&存储条件

分子量	532.53
分子式	C24H27F3N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(3,3-Difluorocyclobutyl)oxy]-N-[6-[(3R)-3-fluoro-4-[4-[(methylamino)carbonyl]-1H-1,2,3-triazol-1-yl]butyl]-3-pyridazinyl]-6-methyl-2-pyridineacetamide

参考文献

1. Soth MJ, et al. J Med Chem. 2020 Nov 12;63(21):12957-12977.

IPN60090 (IACS-6274, IACS6274, IPN 60090 )

生物&药学活性

物理化学性质&存储条件

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IPN60090 (IACS-6274, IACS6274, IPN 60090 )

生物&药学活性

物理化学性质&存储条件

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