IPI-9119 |CAS:1346564-56-4 Probechem Biochemicals

Chemical Structure : IPI-9119

CAS No.: 1346564-56-4

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IPI-9119 (IPI9119;IPI 9119)

货号: PC-35893Not For Human Use, Lab Use Only.

IPI-9119 (IPI9119) is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.3 nM in biochemical assays.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

IPI-9119 (IPI9119) is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.3 nM in biochemical assays.
IPI-9119 inhibits PCa cell growth and induces cell cycle arrest and apoptosis, induces a profound metabolic reprogramming in PCa cells.
IPI-9119 also inhibits AR-FL and AR-V7 protein expression and induces ER stress response and protein translation inhibition, inhibits AR transcriptional activity and enhances enzalutamide efficacy in CRPC cells.
IPI-9119 inhibits tumor growth of CRPC xenografts and human mCRPC-derived organoids.

物理化学性质&存储条件

分子量	495.443
分子式	C24H19F2N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(2,6-difluorophenyl)-N-isopropyl-5-oxo-4,5-dihydro-1H-tetrazole-1-carboxamido)-3-phenoxybenzoic acid

参考文献

1. Zadra G, et al. Proc Natl Acad Sci U S A. 2018 Dec 21. pii: 201808834. doi: 10.1073/pnas.1808834116.

IPI-9119 (IPI9119;IPI 9119)

生物&药学活性

物理化学性质&存储条件

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IPI-9119 (IPI9119;IPI 9119)

生物&药学活性

物理化学性质&存储条件

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