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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-IPI-3063
IPI-3063

Chemical Structure : IPI-3063

CAS No.: 1425043-73-7

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IPI-3063 (IPI 3063, IPI3063)

货号: PC-60565Not For Human Use, Lab Use Only.

IPI-3063 is apotent, and selective p110δ PI3K inhibitor with IC50 of 0.1 nM in cell-based assays.

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10 mg ￥2480 In stock
25 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IPI-3063 is apotent, and selective p110δ PI3K inhibitor with IC50 of 0.1 nM in cell-based assays.
IPI-3063 displays >100-fold selectivity over p110α, p110β and p110γ.
IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1.
IPI-3063 potently inhibits human B cell proliferation in vitro at 10 nM, but not the p110γ selective inhibitor AS-252424.

物理化学性质&存储条件

分子量 455.522
分子式 C25H25N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-4-amino-6-((1-(2-isopropyl-8-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1-oxo-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile

参考文献

1. Chiu H, et al. Front Immunol. 2017 Jun 30;8:747.

2. Winkler DG, et al. Chem Biol. 2013 Nov 21;20(11):1364-74.

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