IPHBA

Chemical Structure : IPHBA

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货号: PC-47049Not For Human Use, Lab Use Only.

IPHBA is a small-molecule inhibitor that suppresses EPAS1-driven IL-31 induction, selectively inhibits TCR-mediated IL-31 induction in murine CD4+ T cells with IC50 of 10.6 uM.

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生物&药学活性

IPHBA is a small-molecule inhibitor that suppresses EPAS1-driven IL-31 induction, selectively inhibits TCR-mediated IL-31 induction in murine CD4+ T cells with IC50 of 10.6 uM.
IPHBA inhibits the association between EPAS1 and SP1, and impairs recruitment of both transcription factors to the specific sites of the IL31 promoter.
IPHBA inhibits IL-31 induction in murine and human TH cells without affecting other cytokine production and hypoxic responses.

物理化学性质&存储条件

分子量	282.343
分子式	C17H18N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-isopropylbenzylidene)hydrazineyl)benzoic acid

参考文献

1. Yasuhisa Kamikaseda, et al. J Allergy Clin Immunol. 2021 Aug;148(2):633-638.

IPHBA

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物理化学性质&存储条件

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IPHBA

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